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MCAT Question A Day - 4/11/14 - Answer!

Human blood types are most often examined in reference to the ABO gene locus. The IA and IB alleles are both dominant to the iO allele. If blood from a type AB individual were donated to three individuals who were, respectively, types A, B, and O, which of the recipients’ blood would agglutinate?

A.  The recipients with blood types A and B
B.  The recipient with blood type O
C.  None of the above
D.  All of the above

The correct answer is (D). This question requires an understanding of Mendelian genetics and antigen-antibody relationships. The A and B antigens on the RBCs donated from the Type AB donor will be agglutinated by anti-B in the plasma of the Type A recipient, anti-A (in the Type B recipient), and both anti-A and anti-B (in the Type O recipient).

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